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The original rationale for high dose methotrexate therapy was based on the concept of selective rescue of normal tissues by leucovorin.

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remember methotrexate mtx is to be taken only once weekly.

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do not give methotrexate to other people, even if they have the same symptoms that you have.

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lef, leflunomide; mtx, methotrexate; ssz, sulphasalazine; plc, placebo.

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be sure to mention the medications listed in the important warning section and any of the following alprazolam niravam, xanax ; angiotensin ii receptor antagonists such as azilsartan edarbi , candesartan atacand , eprosartan teveten , irbesartan avapro, in avalide , losartan cozaar, in hyzaar , olmesartan benicar, in azor , telmisartan micardis , or valsartan diovan, in exforge ; lithium lithobid ; medications for seizures such as carbamazepine equetro, tegretol or phenytoin dilantin ; methotrexate otrexup, rheumatrex, trexall ; muscle relaxants; selective serotonin reuptake inhibitors ssris such as citalopram celexa , duloxetine cymbalta , escitalopram lexapro , fluoxetine prozac, sarafem, in symbyax, others , fluvoxamine luvox , paroxetine paxil, pexeva , and sertraline zoloft ; or thiothixene navane .

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for full prescribing information, refer to the methotrexate injection, usp preservative-free us package insert as there are significant differences in information such as adverse events, boxed warnings, and preparation and administration instructions.

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