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The effects of substrate concentration on the rate of s -oxidation for clindamycin were determined in three human liver microsomal preparations and are listed in table 1.

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inducible clindamycin resistance was detected by d test, as per clsi guidelines on erythromycin resistant isolates.

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in vitro routine tests for clindamycin susceptibility may fail to detect inducible clindamycin resistance due to erm genes resulting in treatment failure, thus necessitating the need to detect such resistance by a simple d test on routine basis.

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