Deflazacort is a cyp3a4 substrate; isoniazid is a moderate inhibitor of cyp3a4.
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although isoniazid is dialyzable, dialysis is not recommended because it takes too long.
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also in common with isoniazid, these agents are prodrugs that require activation by an enzyme encoded by the etha locus but less than half the mutations conferring resistance to this agent occur in this locus.
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although it is not a first-line treatment, combination therapy with isoniazid and rifampin for three months is another alternative treatment option in select circumstances.
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do not take this medicine with any of the following medications -delavirdine -ibrutinib -ranolazine this medicine may also interact with the following medications -albendazole -alcohol -antiviral medicines for hiv or aids -aspirin and aspirin-like medicines -certain medicines for blood pressure like nifedipine, nimodipine, and verapamil -certain medicines for cancer -certain medicines for cholesterol like atorvastatin, simvastatin, and fluvastatin -certain medicines for depression, anxiety, or psychotic disturbances -certain medicines for fungal infections like ketoconazole and itraconazole -certain medicines for irregular heart beat like amiodarone and quinidine -certain medicines for seizures like carbamazepine, phenobarbital, and topiramate -certain medicines for stomach problems like cimetidine and omeprazole -chloramphenicol -cyclosporine -diazoxide -digoxin -disulfiram -doxycycline -female hormones, like estrogens and birth control pills -furosemide -halothane -isoniazid -medicines that relax muscles for surgery -methylphenidate -narcotic medicines for pain -phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine -praziquantel -reserpine -rifampin -st.
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