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The average magnitude of the effect on plasma levels of cyp2d6 substrates is as follows paroxetine, a 327 421 increase 1, 2, 20 ; fluoxetine, a 380 640 increase 9, 75 ; citalopram, a 47 increase 40 ; sertraline, a 0 37 increase 2, 50, 75 ; and fluvoxamine, a 14 increase 90 .

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